表观遗传学概念涵盖范围较广，组蛋白修饰、染色质构象改变、DNA修饰、RNA修饰、非编码RNA调控等均可以在不改变核苷酸序列的前提下，进而影响基因的转录调控、疾病的发生和进展等，一直是组学研究不可或缺的方向。天昊生物尤其在DNA修饰、RNA修饰、非编码RNA调控等方向有丰富的项目经验，协助客户发表了多篇高水平文章。

表观遗传方向部分客户文章

1. A multiplex blood-based assay targeting DNA methylation in PBMCs enables early detection of breast cancer, Nature Communications, 2023.

2. DNA methylation-based testing in peripheral blood mononuclear cells enables accurate and early detection of colorectal cancer, Cancer Research, 2023.

3. ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1, Molecular Cancer, 2020.

4. DNA hydroxymethylation reprogramming of β-oxidation genes mediates early-life arsenic-evoked hepatic lipid accumulation in adult mice, Journal of Hazardous Materials, 2022.

5. Pan-cancer analysis of genome-wide methylation profiling discover type-specific markers targeting circulating free DNA for the detection of colorectal cancer, Clinical and Translational Medicine, 2023.

6. Rheumatoid arthritis–associated DNA methylation sites in peripheral blood mononuclear cells, Annals of the Rheumatic Diseases, 2018.

表观遗传方向部分课件内容