A multiplex blood-based assay targeting DNA methylation in PBMCs enables early detection of breast cancer

PBMC中靶向DNA甲基化的多重血液检测能够实现乳腺癌早期诊断

Nature Communications

2023

DNA methylation-based testing in peripheral blood mononuclear cells enables accurate and early detection of colorectal cancer

基于DNA甲基化的外周血单个核细胞检测能够准确、早期诊断结直肠癌

Cancer Research

2023

DNA hypermethylation-induced miR-182 silence targets BCL2 and HOXA9 to facilitate the self-renewal of leukemia stem cell, accelerate acute myeloid leukemia progression, and determine the sensitivity of BCL2 inhibitor venetoclax

DNA高甲基化诱导miR-182沉默，上调靶基因BCL2和HOXA9，促进白血病干细胞自我更新，从而加速AML进展，并确定BCL2抑制剂维奈托克的敏感性

Theranostics

2023

The impact of HTR1A and HTR1B methylation combined with stress/genotype on early antidepressant efficacy

HTR1A和HTR1B甲基化结合应激/基因型与抗抑郁疗效相关

Psychiatry and Clinical Neuroscience

2022

Combined HTR1A/1B methylation and human functional connectome to recognize patients with MDD

联合HTR1A/1B甲基化和人类功能连接组识别MDD患者

Psychiatry Research

2022

DNA hydroxymethylation reprogramming of β-oxidation genes mediates early-life arsenic-evoked hepatic lipid accumulation in adult mice

β-氧化相关基因羟甲基化重塑介导了成年小鼠早期砷诱发的肝脏脂质积累

Journal of Hazardous Materials

2022

DNA methylations of brain-derived neurotrophic factor exon VI are associated with major depressive disorder and antidepressant-induced remission in females

脑源性神经营养因子第六外显子的DNA甲基化与女性的重度抑郁症和抗抑郁剂治疗的疾病缓解有关

Journal of Affective Disorders

2021

Association between methylation of BIN1 promoter in peripheral blood and preclinical Alzheimer’s disease

外周血中BIN1启动子的甲基化与临床前阿尔茨海默病的关系

Translational Psychiatry

2021

Rheumatoid arthritis-associated DNA methylation sites in peripheral blood mononuclear cells

外周血单核细胞中类风湿关节炎相关的DNA甲基化位点

Annals of the Rheumatic Diseases

2018

Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case-control study

黄体酮和SOCS3 DNA甲基化对T2DM的联合作用：一项病例对照研究

Clinical Epigenetics

2021

Identification and validation of prognosis-related DLX5 methylation as an epigenetic driver in myeloid neoplasms

髓系肿瘤中与预后相关的DLX5甲基化作为表观遗传驱动因素的鉴定和验证

Clinical and Translational Medicine

2021

Genome-wide methylation sequencing identifies progression-related epigenetic drivers in myelodysplastic syndromes

全基因组甲基化测序鉴定骨髓增生异常综合征进展相关的表观遗传驱动因素

Cell Death & Disease

2021

The relationship between PRDM16 promoter methylation in abdominal subcutaneous and omental adipose tissue and obesity

腹部皮下和网膜脂肪组织中PRDM16启动子甲基化与肥胖的关系

Clinical Nutrition

2021

Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia

肥胖相关基因LEP甲基化作为急性髓性白血病患者预后指标的鉴定和验证

Clinical Epigenetics

2021

DNA Methylation Patterns in the HLA-DPB1 and PDCD1LG2 Gene Regions in Patients with Autoimmune Thyroiditis from Different Water Iodine Areas

不同水碘区自身免疫性甲状腺炎患者HLA-DPB1和PDCD1LG2基因区DNA甲基化模式

Thyroid

2021

Deoxyribonucleic acid methylation signatures in sperm deoxyribonucleic acid fragmentation

精子脱氧核糖核酸断裂中的DNA甲基化特征

Fertility and Sterility

2021